CAMPTOTHECIN AND KHAT (CATHA EDULIS FORSK.) INDUCED DISTINCT CELL DEATH PHENOTYPES INVOLVING MODULATION OF C-FLIPL, MCL-1, PROCASPASE-8 AND MITOCHONDRIAL FUNCTION IN ACUTE MYELOID LEUKEMIA CELL LINES

Abstract Background An organic extract of the recreational herb khat (Catha edulis Forsk.) triggers cell death in various leukemia cell lines in vitro.The chemotherapeutics camptothecin, a plant alkaloid topoisomerase I inhibitor, was tested side-by-side with khat in a panel of acute myeloid leukemia cell lines to elucidate mechanisms of toxicity.R

Road information Luminizers has a key role in many applications such as transportation, automatic navigation, traffic management, crisis management, and also to facilitate and accelerate updating databases in a GIS.Therefore in the past two decades, automatic road extraction has become an important issue in remote sensing, photogrammetry and comput

Climate change has been thought to drive the accelerated expansion of global drylands.However, many studies reveal that Arid Central Asia (ACA) has been warming and wetting in recent decades, representing an anomalous response to global climate change.Given that ACA is composed of complex ecosystems and landforms, it is Data Transfer Cables not cle

BackgroundPapua New Guinea (PNG) has a high burden of lymphatic filariasis (LF) caused by Wuchereria bancrofti, with an estimated 4.2 million people at risk of infection.A single co-administered dose of ivermectin, diethylcarbamazine and albendazole (IDA) has been shown to have superior efficacy in sustained clearance of microfilariae compared to d